Rheumatoid arthritis (RA) is a common condition affecting approximately 1% of the general population. RA is a multisystem disorder that causes progressive articular destruction through synovial inflammation. One of the most common extraarticular manifestations of RA is pulmonary involvement, where all compartments of the pulmonary system can be impacted (e.g., pulmonary vasculature, pleura, parenchyma, and the airways).
Although it has been known for decades that a portion of patients with RA develop interstitial lung disease, and recent advancements in understanding the genetic risk and treatment for RA-interstitial lung disease have drawn attention, more recent data have begun to highlight the significance of airway disease in patients with RA. Yet, little is known about the underlying pathogenesis, clinical impact, or optimal treatment strategies for airway disease in RA. This review will focus on airway disease involvement in patients with RA by highlighting areas of clinical inquiry for pulmonologists and rheumatologists and discuss areas for future research.
Finally, we discuss a potential screening algorithm for providers when approaching patients with RA with respiratory complaints.
Pulmonologists, critical care specialists, translational researchers, and clinicians
At the conclusion of this activity, learners should be able to:
- Appropriately collaborate with rheumatologists when approaching airways disease in rheumatoid arthritis patients.
- Select the appropriate method for airway disease management when treating patients with rheumatoid arthritis (RA) inflammation and RA disease.
- Initiate earlier symptom-based screening, when appropriate, for airways disease in rheumatoid arthritis patients.
1.00 AMA PRA Category 1 Credit
The American Thoracic Society is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.
|Credit Type||Credit/Points||Credit Designation Statement|
|AMA PRA Category 1 Credit™||1.00||The American Thoracic Society designates this Journal for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.|
Article Authorship Disclosures (as submitted to the ATS prior to article publication date)
Scott M. Matson, M.D. (University of Kansas School of Medicine, Kansas City, KS) reported no relevant financial relationships.
M. Kristen Demoruelle, M.D., Ph.D. (University of Colorado at Denver, Aurora, CO) reported receiving grants from Pfizer.
Mario Castro, M.D., M.P.H. (University of Kansas School of Medicine, Kansas City, KS) reported receiving grants from NIH, ALA, PCORI, AstraZeneca, GSK, Novartis, Pulmatrix, Sanofi-Aventis, and Shionogi; receiving royalties from Elsevier; receiving consulting fees from Genentech, Teva, and Sanofi-Aventis, Novartis; and receiving payment for speaking or lectures from AstraZeneca (Unbranded disease state only), Genentech, GSK, Regeneron, Sanofi, and Teva..
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