Back To Basics: Harnessing The Power Of Mouse Models To Understand Human Sepsis

Back To Basics: Harnessing The Power Of Mouse Models To Understand Human Sepsis

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Session date: May 22, 2023

Sepsis, the dysregulated host response to infection, is a life-threatening clinical syndrome affecting all cells, tissues, and organs. While no pre-clinical model can recapitulate the myriad complexities of organ dysfunction and tissue injury in human sepsis, animal models are essential to developing a mechanistic understanding of sepsis and identifying novel targets for intervention. This symposium will provide attendees with a basic overview of commonly used mouse models of sepsis, with an emphasis on how these models provided new insights directly relevant to human sepsis.

• Describe new mechanistic insights into human sepsis derived from pre-clinical mouse models
• Understand and identify perceived and actual barriers to translating pre-clinical findings to the clinic
• Identify new strategies to limit infection-induced inflammation

James Colbert, MD
William Bain, MD
Julie Bastarache, MD
Christopher Hunter, PhD

Utilizing Complementary Murine Models of Experimental Sepsis to Determine How Age Increases the Virulence of Gut-Derived Pathogens
Preserved Alternative Complement Function is Associated with Improved Survival During ARDS: A Translational Perspective
A Clinically Relevant Mouse Model of Sepsis-Induced Delirium
Cytokine Networks That Limit Infection-Induced Inflamation