This session will focus on the critical balance between pro-inflammatory signaling and negative feedback control of inflammation in initiating recovery from lung injury. Attendees will gain insight into the temporal dynamics of cytokine expression in COVID-19 in relationship to other forms of ARDS. Key endogenous resolution pathways, including lipid resolving factors, epithelial progenitors, and corticosteroids as master regulators of inflammatory resolution and repair, will be presented in relationship to COVID-19, ARDS and chronic lung disease. In aggregate, this symposium will provide a framework for understanding challenges and opportunities in targeting host pathways that control the resolution of lung inflammation.
CME credits and/or Certificates of Completion are not provided for this session.
1- Learn new findings about the role of negative feedback control and repair in therapy and recovery from lung injury and COVID-19
2- Integrate new findings about inflammatory resolution and repair into discussing treatment options with patients and their families
3- Improve design of research studies aimed at understanding the role of host immune response versus inflammatory resolution in the recovery from acute lung injury, infection and ARDS
Angela Rogers, MD, MPH, ATSF: Cytokines in ARDS and COVID-19: Decoding Temporal Heterogeneity
Reinoud Gosens, PhD: Airway Epithelial Progenitors and the Resolution of Infection-Driven Lung Injury
Anthony N. Gerber, MD, PhD: Corticosteroids and Inflammatory Resolution: A Master Regulator of Feedback Control
Rachel Zemans, MD: Summary and Conclusions
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