We are all aging. Yet the machinery of aging is not well understood. Many disorders with which clinicians struggle are strongly age-associated (UIP/IPF, COPD, Th1 ASTHMA, Lung Cancer, others). Some central dysfunctions of aging include stochastic deterioration of biologic programs; senescence programming, oxidative damage, telomeric maintenance failure, immunologic exhaustion, and other processes. This symposium will review some of the known processes of aging as they relate to the lung, review some of the most salient studies, and reach for a unified theme for normal as well as accelerated lung aging that may be addressable with preventatives and therapeutics.
• Describe new findings about the major pathophysiologic elements of the aging lung
• Apply the pathophysiology of lung aging to better manage the common clinical scenarios of ILD, COPD, Th1 asthma, lung carcinogenesis
• Improve the healthspan of individuals at risk for age-related lung disorders, including the consideration of "senolytic" prevention maneuvers
Jaime Schneider, MD, PhD
Irfan Rahman, PhD, ATSF
Simon Spivack, MD, MPH
Janette Burgess, BSc, PhD, ATSF
Renat Shaykhiev, MD, PhD
Basak Ural, PhD
Naftali Kaminski, MD, ATSF
Simon Spivack, MD, MPH
Overview of Lung Aging
Oxidative Shifts in the Aging Lung
Mutation and Epimutation Changes with Age
Extracellular Matrix and Aging in the Lung
Distal Bronchoalveolar Region Changes in Aging and COPD
Immunologic Signaling and Exhaustion in the Aging Lung
Multiomic Revelations in Lung Aging and IPF
Panel Discussion