This session will highlight the bidirectional mechanisms between opioid use disorder (OUD) and sleep deficiency. It will discuss how targeting sleep deficiency and control of breathing with therapeutic interventions can promote long-term, healthy recovery among patients in OUD treatment. Current knowledge on the effects of opioids on sleep architecture, sleep-disordered breathing, sleep apnea endotypes, ventilatory control, and and clinical practice are highlighted. Finally, an actionable research agenda is provided to evaluate the basic mechanisms of the relationship between sleep deficiency and OUD and the potential for behavioral, pharmacologic, and positive airway pressure treatments targeting sleep deficiency to improve OUD outcomes.
• Have an improved understanding of the bidirectional mechanisms between opioid use disorder (OUD) and sleep deficiency
• Describe efforts to target sleep deficiency and control of breathing with therapeutic interventions to promote long-term healthy recovery among patients with OUD
• Outline an actionable research agenda to evaluate the basic mechanisms of the relationship between sleep deficiency and OUD and the potential for behavioral, pharmacologic, and positive airway pressure treatments to improve OUD treatment outcomes.
Danny Eckert, PhD
Henry Yaggi, MD
Susmita Chowdhuri, MD, MS, ATSF
Vsevolod Polotsky, MD, PhD
Aaron Laposky, PhD
Current Knowledge on the Effects of Opioids on Sleep Quality, Sleep Architecture, Sleep-Disordered Breathing, Sleep Apnea Endotypes
Sleep Deficiency Across the Trajectory of OUD: Neuro-Biologic, Neuro-Psychiatric, and Social-Ecologic Mechanisms
PAP Therapies for Sleep-Disordered Breathing OUD
Novel Pharmacologic Treatments Targeting Control of Breathing in Opioid Use: Intranasal Leptin, Ampakines, and Other Potential Targets
Sleep Deficiency as a Core Feature of OUD and Recovery: A Research Agenda