Perinatal Origins of Pulmonary Vascular Disease: Mechanisms and Therapies

Perinatal Origins of Pulmonary Vascular Disease: Mechanisms and Therapies

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Pulmonary hypertension (PH) remains a frequent and fatal complication of developmental lung disorders, including bronchopulmonary dysplasia (BPD), congenital diaphragmatic hernia (CDH), and alveolar capillary dysplasia (ACD). The management of patients with these disorders is also challenging because most of them respond poorly to the commonly used pulmonary vasodilators. Additionally, the presence of PH increases mortality and adult cardiopulmonary disorders in infants with perinatal pulmonary vascular disease. This symposium will provide attendees with a basic understanding of biological mechanisms, meaningful therapeutic strategies, and lifelong cardiopulmonary consequences of BPD, CDH, ACD, and prematurity. 

CME credits and/or Certificates of Completion are not provided for this session.

1- Learn how deregulated signaling of blood vessels, exosomes, and stem cells contribute to the pathogenesis of pulmonary hypertension (PH) in infants

2- Improve the health of patients with developmental lung disorders and PH by analyzing and applying evidence-based strategies to manage PH in these infants

3- Recognize the developmental origins of adult cardiopulmonary diseases

Binoy Shivanna, MD, DM, PhD: Introduction

Steven H. Abman, MD: Angiogenic Targets for the Prevention of PH-Associated BPD

Vladimir Kalinichencko, MD, PhD: Endothelial Progenitor Cells in Developmental Lung Disease

Karen Cecile Young, MD: Regenerative Stem Cell Therapy in PH associated with BPD and CDH

Namasivayam Ambalavanan, MD: Exosomes in PH Associated with BPD and CDH

Sharon A. McGrath-Morrow, MD: An Evidence-Based Approach to Diagnose and Manage PH in BPD infants

Satyan Lakshminrusimha, MD, MBBS: An Evidence-Based Approach to Diagnose and Manage PH in CDH Infants

Kara Goss, MD: Cardiopulmonary Disorders of Adults Born Preterm

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