The majority of COPD-related morbidity, mortality and healthcare costs are due to acute exacerbations, particularly those that require hospitalization. Although significant advances have been made in phenotyping and treating stable COPD, the management of acute exacerbation has not changed significantly in several decades. Recent data indicates there is considerable heterogeneity in exacerbations also, and that there is a need to identify separate endo-phenotypes. Speakers will discuss current and alternative definitions of acute exacerbations, the clinical relevance of exacerbation severity, phenotypes and endotypes of exacerbations, underappreciated causes of exacerbations, biomarkers and the therapy of exacerbations.
CME credits and/or Certificates of Completion are not provided for this session.
1- Learn current and alternate definitions of acute exacerbations, and estimate exacerbation severity and its importance in patient care
2- Appreciate etiology and clinical course based endotyping and phenotyping of exacerbations
3- Gain new knowledge of biomarkers and therapies of exacerbations
Surya P. Bhatt, MD, MSPH: Introduction
Alvar Agusti, MD: Definition of Acute Exacerbations: Are We There Yet?
Jadwiga A. Wedzicha, MD, ATSF: Clinical Phenotypes of Exacerbations
Stephanie Christenson, MD, MS: Molecular Phenotyping of Exacerbations Using Genomic Approaches
Surya P. Bhatt, MD, MSPH: Under Recognized Etiologies of Exacerbations
Donald D. Sin, MD: Biomarkers for Acute Exacerbations: Challenges and Promise
Fernando J. Martinez, MD, MS: Treatment of Exacerbations: Do They Need More Nuance?
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