Quantification Of Environmental Exposures Using State-Of-The-Art Methods

Quantification Of Environmental Exposures Using State-Of-The-Art Methods

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Session date: May 21, 2023

This is part 1 of a 2-part symposium

Part 1 focuses on quantification of environmental exposures using state-of-the-art methods.

Part 2 on Sunday, May 21, 2:15 p.m.-3:45p.m. focuses on the physiological and cellular impact of environmental exposures.

Occupational and environmental lung diseases are caused by the inhalation of chemical irritants, allergens or toxins in work or home environments. Most diseases are caused by repeated, long-term exposure, but even a one-time or indirect contact with a hazardous agent can result in lung diseases with lasting effects.
Environmental exposures related to fossil fuel and heavy metals and occupational exposures related to silica and coal mining generate oxidative stress and inflammation in the lungs. Sustained oxidative stress causes DNA damage, epigenetic instability, mitochondrial dysfunction, and cell cycle arrest in key progenitor cells in the lung.
Inhaled environmental exposures accelerate lung aging by injuring the lungs and damaging the cells responsible for wound healing. Novel exposure assessment methods, including functional imaging and –omics studies, together with mathematical models are needed to quantify environmental exposures. Interventions that minimize exposure to noxious antigens are critical to improve lung health, and novel research is required to expand our knowledge of therapies that may slow or prevent premature lung aging.
Each presentation will leave 5 minutes for questions and answers.

• Identify opportunities for novel investigation into understudied aspects of exposure assessment, (patho)physiological mechanisms, and cellular and molecular biology
• Apply new technologies such as functional imaging and in vitro translational models for detecting onset and progression of lung function changes to environmental exposures
• Learn how advances in lung biology are revealing new mechanisms of lung homeostasis and therapeutic targets to reduce/ reverse the deleterious impacts of environmental exposures

Ilona Jaspers, PhD
R. Graham Barr, MD, DrPH
Christopher Carlsten, MD, MPH
Tillie-Louise Hackett, PhD, ATSF

Quantifying Vaping-Related Pulmonary Illnesses
Long-Term Exposure to Ambient Air Pollution and Change in Quantitatively Assessed Emphysema and Lung Function - Presentation withheld at the speaker's request
Identifying Epigenetic Modifications to Allergens and Pollution
Visualizing Lung Destruction and Repair to Environmental Exposures - Presentation withheld at the speaker's request