Growing evidence suggests that early-life environmental exposures (e.g., airway infection, nutrition, air pollution) contribute to the risk of developing asthma in childhood and beyond. During early-life development, environmental exposures interact with both the expression and function of human genetic/epigenetic factors and lead to differential disease risks. This session will highlight examples of recent studies from the NIH-supported Environmental Influences on Child Health Outcomes (ECHO) Program that offer deeper insights into the integrated roles of early-life environmental exposures, genetics, and epigenetics in incident asthma and the development of primary prevention strategies for asthma providers.
• Understand the potential and limitations of genetics, epigenetics, and integrated omics approaches in examining asthma pathogenesis
• Gain an understanding of the link between early-life exposures and asthma development
• Understand the integrated role of environmental exposures and multi-omics in incident asthma
Carole Ober, PhD
Lyndsey Shorey-Kendrick, PhD, BA
Zhaozhong Zhu, ScD
Rachel Kelly, MPH, PhD
LaJoy Johnson-Law
DNA Methylation Signatures of Early Life Exposures and Genetic Variation as Mediators of Asthma and Allergies in Childhood
Vitamin C Supplementation to Maternal Smokers During Pregnancy: Stable Effects on Offspring Wheeze and Buccal DNA Methylation Through 5 Years of Age
Viral Bronchiolitis, Nasal Airway MicroRNA, and Risk for Developing Asthma
Integrative Metabolomics and the Early Life Origins of Asthma
A Patient's Perspective