This exciting Scientific Symposium explores the role of the circadian clock in the development of chronic lung disease. This session is fully translational, providing a bench-to-bedside view of clock biology, basic mechanisms of circadian clock dysregulation in development of OSA, COPD, and IPF, and clinical translation drawing on results of chronotherapy trials in asthma, showing the role of environmental influences on circadian biology and learning from individuals with sleep disorders. We have assembled an impressive and diverse group of speakers from across the globe and this promises to be an exceptional session.
• Learn on the newly and rapidly evolving paradigms about circadian clock regulation in innate immunity, sleep and pathogenesis of chronic lung diseases
• Identify potential clock targets that can modulate cellular functions and molecular pathways essential for lung development and for the treatment and management of chronic inflammatory lung diseases
• Identify novel biomarkers that supports circadian disruption causal-effect relationships in chronic lung diseases progression; Develop novel clock-based targeted therapies that can ameliorate pathophysiological phenotypes of chronic lung diseases
Victoria Revel, PhD
David Smith, MD, PhD
Hannah Durrington, PhD, MA, MBChB
Irfan Rahman, PhD, ATSF
Isaac Kirubakaran Sundar, BSc, MSc, PhD
John Hogenesch, PhD
Sleep and Circadian Rhythms: Considerations for Diagnosis, Monitoring and Treatment
Impact of Intermittent Hypoxia on Circadian Dysregulation of Gene Expression and Physiology
Asthma… It’s a Matter of Time!
Clock in the Lung: How Environmental Cues Tik Tok
Tik Tok of Pulmonary Fibrosis Using in Vitro and In Vivo models
Bringing Circadian Biology to Medicine