Session date: May 22, 2023
Sepsis, the dysregulated host response to infection, is a life-threatening clinical syndrome affecting all cells, tissues, and organs. While no pre-clinical model can recapitulate the myriad complexities of organ dysfunction and tissue injury in human sepsis, animal models are essential to developing a mechanistic understanding of sepsis and identifying novel targets for intervention. This symposium will provide attendees with a basic overview of commonly used mouse models of sepsis, with an emphasis on how these models provided new insights directly relevant to human sepsis.
Sepsis, the dysregulated host response to infection, is a life-threatening clinical syndrome affecting all cells, tissues, and organs. While no pre-clinical model can recapitulate the myriad complexities of organ dysfunction and tissue injury in human sepsis, animal models are essential to developing a mechanistic understanding of sepsis and identifying novel targets for intervention. This symposium will provide attendees with a basic overview of commonly used mouse models of sepsis, with an emphasis on how these models provided new insights directly relevant to human sepsis.
• Describe new mechanistic insights into human sepsis derived from pre-clinical mouse models
• Understand and identify perceived and actual barriers to translating pre-clinical findings to the clinic
• Identify new strategies to limit infection-induced inflammation
James Colbert, MD
William Bain, MD
Julie Bastarache, MD
Christopher Hunter, PhD
Utilizing Complementary Murine Models of Experimental Sepsis to Determine How Age Increases the Virulence of Gut-Derived Pathogens
Preserved Alternative Complement Function is Associated with Improved Survival During ARDS: A Translational Perspective
A Clinically Relevant Mouse Model of Sepsis-Induced Delirium
Cytokine Networks That Limit Infection-Induced Inflamation