Beyond Bioenergetics: Cellular Metabolism In Lung Health And Disease

Beyond Bioenergetics: Cellular Metabolism In Lung Health And Disease

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Session date: May 24, 2023

Cellular metabolism is the fundamental step of bioenergetic process. Growing evidence demonstrates the importance of cellular metabolism in disease pathogenesis beyond energy production. In this session, we will provide key knowledge about major cellular metabolic pathways and present recent discoveries and future perspectives on how these pathways regulate the pathogenesis of pulmonary diseases, such as COPD, pulmonary hypertension, interstitial lung diseases and lung cancer and how they may be targeted to alter disease progression. This session brings together experts who are among the pioneers to explore the new paradigm of cellular metabolic dysregulation as a key manifestation of pulmonary diseases.

• Describe metabolic changes that occur in various cell populations in lung diseases and lung cancer
• Describe the role of mitochondria as signaling organelles in lung cancer
• Recognize disease specific metabolic changes in lungs cell and describe how metabolic pathways may potentially be targeted for treatment

Suzanne Cloonan, PhD
Robert Hamanaka, PhD
Serpil Erzurum, MD
Ross Summer, MD
William Janssen, MD

Metabolic Changes in Immune Cells in COPD
Amino Acid Metabolism in Pulmonary Fibrosis
Metabolism in Pulmonary Hypertension
Lipid Metabolism in Lung Diseases
Macrophage Metabolism in ARDS