Beyond The Lungs: Extrapulmonary Manifestations Of Pulmonary Vascular Disease

Beyond The Lungs: Extrapulmonary Manifestations Of Pulmonary Vascular Disease

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Session date: May 22, 2023

This session will provide a comprehensive review of extrapulmonary manifestations of pulmonary arterial hypertension (PAH). Several systems will be reviewed including the central nervous system, skeletal musculature, endocrinological manifestations and the immune system. Presenters will provide a review of the literature from bench to bedside observations and proposed pathophysiological mechanisms. Therapeutic implications and knowledge gaps will also be highlighted. By the conclusion of this session, learners will understand how PAH may affect multiple extrapulmonary systems and how the multi-system interplay in the development of this complex disease may contribute to clinical outcomes.

• Describe new findings about extrapulmonary manifestations in PAH within the CNS, skeletal musculature, gut microbiome and changes in systemic inflammation, endocrine and metabolic function
• Define new strategies to manage the care of PAH including the role that pulmonary rehabilitation may play and how novel therapeutic targets addressing inflammation and metabolism may prove to improve clinical outcomes
• Apply new findings toward novel research questions and continue investigation of how these systemic effects of PAH may play a role in disease development and outcomes

Soban Umar, MD, PhD
Thenappan Thenappan, MD
Nadine Al-Naamani, MD, MS
Evan Brittain, MD
Tim Lahm, MD, ATSF

Spinal Cord Neuroinflammation in PAH
Gut Microbiome and Systemic Inflammation in PAH
Obesity and Metabolic Dysfunction in PAH
Skeletal Muscle and Exercise in PAH
Retinal Involvement in PAH