The term “advanced sarcoidosis” is used for forms of sarcoidosis with a significant risk of loss of organ function or death. Advanced sarcoidosis often involves the lung and is described as “adv...

Opioid use continues to rise globally. So too do the associated adverse consequences. Opioid use disorder (OUD) is a chronic and relapsing brain disease characterized by loss of control over opi...

Oxygen supplementation is one of the most common interventions in critically ill patients. Despite over a century of data suggesting both beneficial and detrimental effects of supplemental oxyge...

The pulse oximeter is a ubiquitous clinical tool used to estimate blood oxygen concentrations. However, decreased accuracy of pulse oximetry in patients with dark skin tones has been demonstrate...

Reverse triggering dyssynchrony is a frequent phenomenon recently recognized in sedated critically ill patients under controlled ventilation. It occurs in at least 30–55% of these patients and o...

A clinical practice guideline was developed by the American Thoracic Society (ATS) in 2011 regarding the interpretation of FeNO concentrations for clinical applications, but several key question...

Evidence-based guidelines were created in 2021 regarding the pertinence of nucleic acid–based testing of respiratory samples for noninfluenza viral pathogens in adults with suspected community-a...

Home oxygen therapy is prescribed to over 1.5 million Americans at an annual cost of more than $2.9 billion, with cost increasing by 12–13% per year. An evidence-based clinical practice guidelin...